Below are two examples of handlers for the ADD button.
(The first example is not modularized; the second example is)
    Private Sub btnAdd_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) _
                         Handles btnAdd.Click
        '''' Sum the two numbers.
        '''' DECLARATIONS:      
        Dim first As Double
        Dim second As Double
        Dim answer As Double
        '''' INPUT ''''
        first = Val(Me.txtFirst.Text)   ' Convert string to #
        second = Val(Me.txtSecond.Text)
        '''' PROCESSING ''''
        answer = first + second         ' Add numbers
        '''' OUTPUT ''''
        Dim s As String
        Dim t As String
        s = "The sum is "
        t = Format(answer)              ' Convert # to string
        Me.lstAnswers.Items.Add(s + t)
    End Sub
The second code example is fully "modularized" to simplify its "re-use" for other buttons.
    Private Sub btnAdd_Click( ..., ... ) Handles btnAdd.Click
        '''' Input two numbers, process them, produce labelled output.
        Dim first as Integer = getFirst()        '''' INPUT ''''
        Dim second as Integer = getSecond()
        Dim s as String
        '''' PROCESSING ''''        
        answer = calcAdd( first, second )
        s=  "The sum is "
        '******  FOR RE-USE, CHANGE THE ABOVE TWO LINES
        '******  (AND WRITE A NEW calc FUNCTION).
        call saywhat ( s, answer )               '''' OUTPUT ''''
    End Sub
    Function calcaAdd( a as Integer, b as Integer) as Integer
        '''' Add the two numbers.
        Dim result as Integer
        result=  a + b
        return result
    End Function
    '======= INPUT METHODS ========'
    Function getFirst() as Integer
        '''' Get the first input; convert to integer value. ''''
        return Val(Me.txtFirst.Text)   ' Convert string to #
    End Function
    Function getSecond() as Integer
        '''' Get the 2nd input; convert to integer value. ''''
        return Val(Me.txtSecond.Text)   ' Convert string to #
    End Function
    '======= OUTPUT METHODS ========'
    Sub getFirst( msg as string, v as integer )
        '''' Display a message followed by a value.
        Me.lstAnswers.Items.Add( msg + Format(v) )
    End Sub